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A stop-gain variant (p.Arg138*) in the Greenlandic population was associated with markedly reduced type 2 diabetes risk, a finding replicated in the UK Biobank, in which carriers of protein-truncating variants exhibited up to a 65% lower risk of developing diabetes
Concurrently, the focal adhesion pathway was hyperactivated, as evidenced by the upregulated expression of key adhesion and cytoskeletal linker proteins, including Actn1 , Tln1 , and Rac2 (3.1- to 8.5-fold), suggesting enhanced cell-ECM adhesion signaling under HFD
The test reveals predispositions in GIPR, FTO, and MC4R variants, providing context about your metabolic profile
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