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Once these sites are tagged, the receptor can no longer efficiently activate its downstream G protein partners

placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: The SURPASS-5 randomized clinical trial

J Neurosci 35(11):45824586 Cork SC et al (2015) Distribution and characterisation of glucagon-like peptide-1 receptor expressing cells in the mouse brain

The fatty-acid structure surrounding semaglutide might have prevented it from being able to penetrate certain brain regions, such as the hippocampus, which controls memory and cognitive function