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270 AXL also drives MYC-dependent purine biosynthesis, creating nucleotide imbalance and genomic instability, further contributing to resistance
Another difference: PDE5is (especially sildenafil) have interactions (e.g., with high-fat meals delaying absorption, with nitrates causing hypotension)
The absence of human clinical data means every individual is essentially running an n=1 experiment
Just make sure you dont jump to a big dose of fiber all at once, especially if youre just getting started
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