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Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects

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15 Dose adjustment does not appear to be necessary in patients with hepatic impairment, although exenatide has not been specifically studied in this population

Long-term supplementation with L-Carnitine provides beneficial support for the body to use fat for energy allowing to retain muscle mass and enabling better performance