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Chronic exposure to elevated venous pressure is thought to induce structural remodeling of the venous wall, manifested as irregular luminal dilation, which in turn exacerbates local flow turbulence and markedly alters the distribution of shear stress acting on the vessel wall ( 3.3 Structural changes of the venous wall Structural remodeling of the venous wall represents a hallmark histopathological feature of chronic varicocele

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The contribution of BB in gut microbiotadependent l-carnitine metabolism in humans is unknown