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At equimolar doses, this novel compound, GIC-1001 (trimebutine 3-thiocarbamoylbenzene-sulphonate), shows rapid onset of action (2 h) and more effectively mitigates nociceptive responses to colorectal distension, providing pain relief during colonoscopy (Table 4)
Papi A, Contoli M, Gasparini P, Bristot L, Edwards MR, Chicca M, et al
During the Q&A session, Frias was asked whether he was surprised about the safety profile from the trial, as no participants in the combination group withdrew due to adverse events
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