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When To Consult a Doctor While occasional constipation is common and typically not a cause for concern, persistent constipation that significantly impacts your quality of life should be addressed by your doctor, particularly if you've tried over-the-counter remedies like fiber supplements and osmotic laxatives without success
And this response is IL-6-dependent, and this STAT3 activation is almost inhibited in IL-6 deficient mice (Cressman et al., 1996)
Mar Drugs 16(8):247
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