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The APP(V642I) KI mouse model was engineered by introducing the V717I mutation into exon 17 of the mouse APP gene using homologous recombination and the Cre-loxP system
A 2018 review by Sikiric described its effects on the VEGF pathway, which drives the formation of new blood vessels (angiogenesis), and on the nitric oxide system, which regulates blood flow and inflammation
From there, the vitamin B12 is transported into your bloodstream
doi: 10.3390/nu9080866 114
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