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And it can describe drugs, environmental pollutants, or any number of substances
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In fact, oxidative stress can lead to the decrease of DNA-binding activities of activator protein-1 and CREB (cyclic AMP-response element-binding protein) which is associated with the reduction of BDNF (brain-derived neurotrophic factor) gene expression, as well as oxidative stress, and can result in impairment of NMDA channel function that is related to the decrease in BDNF gene expression
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