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1) Trastuzumab emtansine Trastuzumab emtansine (T-DM1) is an anti-HER2 ADC composed of trastuzumab and the cytotoxic microtubule agent emtansine (DM1) linked via a non-cleavable linker, a maytansine derivative [22]

the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science

Among other things, vitamin B12 is also required for the creation of red blood cells and DNA