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Median (Q1 to Q3) body mass index (BMI) was 34 (30 to 38) kg/m2 and median (Q1 to Q3) body weight was 93 (79 to 110) kg
Given that PKC and TRPM5 are downstream effectors of Gq signalling in beta cells, our next step involved determining whether the PKC inhibitor (calphostin C) and TRPM5 blocker (TPPO) suppress the triagonist-induced increase in GSIS
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They also act on receptors in the hypothalamus and brainstem, reducing hunger signals and food-seeking behavior
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