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Pregnant patients or those planning pregnancy should not use either medication, though the reasoning differs (Metformin for potential effects on fetal development, Retatrutide due to insufficient safety data)
Poor compound quality: unverified research-grade peptides may contain degraded or impure product
doi:10.1038/nrn3880 167
The gradual dose titration schedule recommended in the prescribing information is specifically designed to minimize these gastrointestinal effects
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