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This article synthesizes peer-reviewed research on GHK-Cus biological activity and its rapidly expanding applications in clinical aesthetics
electronic Medicines Compendium
First identified in human plasma in the 1970s, this small tripeptide glycyl-L-histidyl-L-lysine, bound to a copper ion has become one of the most extensively referenced compounds in dermal and wound-healing research literature, largely because its copper-binding structure gives it a distinct mechanism from most other peptide sciences on the market
Reported activities include fibroblast stimulation, controlled intracellular copper delivery, modulation of collagen and glycosaminoglycan synthesis, and broad changes in gene expression across stress-response and tissue-repair networks
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