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But to maintain that effect, an IV drip had to run constantly, given the peptides rapid clearance

From the doseinhibition curves established in vitro, circulating GLP-1(936) (~30 pmol/l) can be expected to inhibit glucagon secretion by up to 80%, making it difficult to observe any additional suppression by exogenous administration (especially under normoglycaemic conditions when glucagon secretion is already strongly reduced) (schematic Fig

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