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Retatrutide is a once-weekly injection that mimics three hormones involved in appetite, blood sugar, and how the body uses energy: GLP-1: lowers appetite and blood sugar GIP: lowers appetite and blood sugar Glucagon: increases energy expenditure and the breakdown of stored fat, including fat in the liver The glucagon component is what separates retatrutide from semaglutide, which mimics one hormone (GLP-1), and tirzepatide, which mimics two (GLP-1 and GIP)

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The article reports that clinical trial and observational data describe menstrual irregularities in roughly 15 to 30 percent of women starting GLP-1 therapy, with most changes appearing in the first three months