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Our results should be seen in light of several (additional) limitations, the most important of which is that their cross-sectional nature precludes any assessment of a causal relationship between metabolic health and motivation

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Some research has shown potential benefits in models of Alzheimer's disease and other neurodegenerative conditions, though translating these findings to human cognitive symptoms remains uncertain

A subsequent study of the same region reported increased TRP levels and an elevated KYN/TRP ratio, with KP activation extending to the downstream metabolite 3-HAA [234]