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doi: 10.1093/jn/133.11.3603 80 FultonD

Decision Aid Not sure which GLP-1 option is the right fit

SARS-CoV-2 can activate mitochondrial ROS production, especially in older individuals having ROS overproduction, enhancing oxidative stress and promoting endothelial dysfunction, cardiovascular disease and lung injury

Although SGLT2 inhibitors, metformin, and other agents are well-documented to modulate multiple RCD pathways, it remains unclear whether their clinical renoprotective efficacy is strictly dependent on the specific cell death modality dominant at different stages of DKD progression