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Importantly, although RETA-w/d restored the tumor transcriptome close to that of Veh, the tumor progression remained relatively blunted, which could be due to factors external to the tumor including systemic metabolic effects, such as insulin concentration, which were only partially restored after RETA-w/d, as discussed above
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The presence of leukocytes in the assay could interfere with parasite viability through phagocytosis or other immune mechanism and limit infection of the mosquitoes, and this, therefore, masks the effect of MB
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