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Sehgal NK et al

The patients who see the most complete results are those who address multiple systems simultaneously, because GH decline does not happen in isolation and neither does the recovery from it

Roches 3,500 GPUs thus represent a huge capital expenditure (costing hundreds of millions), but if they shave years off a blockbuster drug development, the ROI could be orders of magnitude in revenue (a successful new obesity drug can make ~$1015 billion per year for its maker)