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23 In a recent study, the serum levels of RANKL, OPG, and 8-hydroxy-2-deoxyguanosine as the marker of oxidative stress were measured to explore the implication of oxidative stress in bone metabolism based on the populations of healthy people and patients with osteoporosis, and the positive and independent correlation between increased oxidative stress markers and the subgroup of osteoporosis was found

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It accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 500 deaths per year due to acute liver failure

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