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In our study, excluding the initial 3 years since the launch of exenatide, the reported cases have averaged nearly 400 per year since 2015
Early GLP-1 development efforts were hindered by rapid degradation by dipeptidyl peptidase-4, short duration of action, and gastrointestinal intolerance at supraphysiologic exposure levels
After reconstitution, it is stable at 4C for 1 week or -20C for longer (with carrier protein)
Temporary side effects may include mild nausea, bloating, or in very rare instances, a skin rash if unregulated products are used
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