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According to a Gallup poll cited by HuffPost, 11% of American adults have taken a GLP-1 medication, up from just 3% in 2024, underscoring how quickly the drugs have become part of mainstream medical care
These results indicate that the increased amount of non-12-OH FXR-antagonistic BAs consequent to the decrease in CYP8B1 expression after T3 treatment potentiates GLP-1 production by deactivating the intestinal FXR, thereby improving glucose homeostasis via the augmentation of insulin secretion
While early Phase 2 data show a promising efficacy profile, the full side effect picture is still emerging
They release cytokines like transforming growth factor-beta (TGF-) and IL-10, which help resolve inflammation and promote tissue repair and remodeling [82]
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