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In cell-based and animal studies, GHRH-receptor agonism (tesamorelin) and GHS-R1a agonism (ipamorelin) have been reported to engage different intracellular signaling cascades that both terminate in growth-hormone secretion, an arrangement investigators have explored for potentially amplified, rather than simply additive, secretory responses
van Delft MAM, Verheul MK, Burgers LE, Derksen V, van der Helm-van Mil AHM, van der Woude D, et al
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