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If constipation becomes problematic, increasing dietary fibre gradually and considering a gentle laxative such as macrogol (typically first-line per NHS guidance) may help
These effects connect directly to the norepinephrine mechanism and tend to be dose-dependent
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Injection site reactions during travel Injection site reactions can be more noticeable during travel due to increased physical activity (walking, carrying luggage) and changes in clothing that may irritate the injection area
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