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A decrease of at least 30% in content was observed in 63% of participants in the 2.4 mg survodutide group, 67% of those in the 4.8 mg group, 57% of those in the 6.0 mg group, and 14% of those in the placebo group

GLP-1RAs can also exert anti-inflammatory effects on macrophages as well as regulating macrophage phenotype [65]

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The peptide functions by mimicking ghrelin, the body's natural "hunger hormone," and binds specifically to GHSR-1a receptors located in the pituitary gland and other tissues throughout the body