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Over the past two decades, his continued research demonstrated that traditional high-speed centrifugation used in the L-PRF protocol led to lower leukocyte yields and diminished growth factor release over time, making the original protocol outdated compared to modern advancements [1]
Excess histamine can also damage the glycocalyxthe protective layer covering cellsleading to inflammation, gut dysbiosis, and higher risks of cardiovascular disease, diabetes, kidney disease, and stroke
2013;17(Suppl 1):S367-S373
PubMed, Crisafulli, Daniel L., et al
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