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Consistent with murine ILC2s, melatonin increased human ILC2 expression of GCLC, the rate-limiting enzyme in glutathione synthesis, as well as NRF2 ( Figures 8B, C )
Inhibition of human tyrosinase requires molecular motifs distinctively different from mushroom tyrosinase
However, under conditions of oxidative stress, superoxide radicals (O2) react with NO to form ONOO , reducing the bioavailability of NO and leading to endothelial dysfunction [67]
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