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J Diabetes Complications (2012) 26(4):26674.10.1016/j.jdiacomp.2012.03.013 139 DAlessioDADenneyAMHermillerLMPrigeonRLMartinJMTharpWGet alTreatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes

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By conducting RNA-seq analysis, SOD activity and malondialdehyde assays in ovaries, as well as ROS staining in oocytes, we revealed that the semaglutide treatment reduced the elevated oxidative stress in ovaries and high ROS levels in oocytes from PPO mice, possibly through activating the PI3K/AKT pathway and improving the state of SOD

But again, these side effects dont usually last long