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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007
Each lot is tested by HPLC for purity, LC-MS for identity confirmation, and endotoxin assay for sterility readiness
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Low-to-moderate intensity cardio (brisk walking, cycling at conversation pace, light jogging) performed in this window maximizes fat oxidation because the exercise intensity keeps the body in a predominantly fat-burning metabolic state
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