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Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, et al
What Were GLPs Originally Used For
4 A 2025 mechanistic study using RAMP1/RAMP3 knockout mice demonstrated this dependence directly: cagrilintide activated area postrema neurons and reduced body weight in wild-type animals but had essentially no effect in mice lacking these receptors, pinning its action to the AMY and AMY subtypes in the hindbrain
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