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Demethylation of key loci can activate reactive astrocyte programs
Treatment durations can range from a few weeks to several months, depending on the desired results
Assays such as ATAC-seq and ChIP-seq have identified distinct open chromatin landscapes near the BIN1 gene locus in both mouse and human microglia, marked by PU.1, H3K27ac, and H3K4me2
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