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Macrobid 100mg twice daily generally causes less nausea than Macrodantin 100mg four times daily due to its sustained-release mechanism, which makes it somewhat more tolerant of alcohols GI effects, though bladder irritation and dehydration concerns remain the same

10.1104/pp.103.035956 141 VadasseryJ.TripathiS.PrasadR.VarmaA.OelmllerR

Latasa MU, Boukaba A, Garca-Trevijano ER, Torres L, Rodrguez JL, Caballera J, Lu SC, Lpez-Rodas G, Franco L, Mato JM, Avila MA (2001) Hepatocyte growth factor induces MAT2A expression and histone acetylation in rat hepatocytes: role in liver regeneration