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This structural modification strategy has been pivotal in the development of GLP-1 receptor agonists with extended plasma half-lives [17]

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6 Beyond the cancer cell itself, the tumor microenvironment (TME), comprising immune cells, stromal components, and extracellular matrix, plays a pivotal role in shaping therapeutic outcomes by fostering immune evasion, altering drug availability, and facilitating cellular crosstalk that promotes resistance