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The initial decrease in body weight is the result of two major effects of SGLT2 inhibition: caloric loss due to glucose excretion (a process also called calorie restriction mimicry) and loss of body water due to osmotic diuresis

10.3390/chemistry6050054 Chemistry 32 Dufoo-HurtadoE.Wall-MedranoA.Campos-VegaR

Therefore, when traveling, its advisable to keep Wegovy in a temperature-controlled environment, whether in your car or while flying