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The most plausible rationale for the discrepancy between preclinical/epidemiological success and clinical failure lies in the fundamental distinction between prevention and treatment
ASCO 14:336, 1995
Iannello A, Thompson TW, Ardolino M, Lowe SW, Raulet DH
Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions
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