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The Right Tools for Weight Loss: Where GLP-1s Lead For a patient whose primary goal is weight loss, the clinical conversation starts with GLP-1 receptor agonists
In July 2025, CVS Caremark made a significant formulary change that affected millions of Aetna members: tirzepatide (Zepbound) was removed from the standard national formulary for obesity
I 2 values of less than 25%, 50%, and more than 75% indicated low, moderate, and high heterogeneity, respectively (with caution)
Side Effect Profiles The most noticeable practical difference is that dual agonists like tirzepatide tend to cause slightly more gastrointestinal side effects than pure GLP-1 agonists
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