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GLP-1 receptor activation increases DNA repair by enhancement of apurinic/apyrimidinic endonuclease 1 (APE1) expression [81]

For twice-daily protocols, alternate between upper-body and lower-body sites (morning injection in abdomen, evening in thigh) to maximise spacing

At 12 months, the on-medication MDS-UPDRS Part III score was 14.9 in the lixisenatide group versus 18.8 in the placebo group, a between-group difference of 3.08 points (P = 0.007) [3]

It can also be sent to peripheral cells for its cholesterol and used in anabolic pathways to build molecules that the cell needs such as hormones that include a cholesterol backbone