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Factors that may contribute to reflux symptoms with semaglutide include: Prolonged gastric retention increasing intragastric pressure Nausea and retching, which can compromise sphincter integrity Changes in eating patterns and meal composition Pre-existing gastroesophageal reflux disease (GERD) that becomes symptomatic Clinical experience and patient reports suggest that some individuals do develop new-onset reflux symptoms or experience worsening of pre-existing GERD after initiating semaglutide therapy

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Aroda VR, Faurby M, Lophaven S, Noone J, Wolden ML, Lingvay I