glp-1 resistance A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces through an Enteric NO-Dependent and Gut-Brain Axis Mechanism Frontiers | GLP−1 receptor agonists

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L.Beck-PeccozP.GebbiaC.GiavoliC.CappielloV.et al

7.2 Comparing with the novel metabolic target drugs As the FXR-activating function of GLP-1RAs, FXR agonists may have the same effect as GLP-1RAs ( In reducing the risk of major adverse liver outcomes and HCC, large-scale observational studies and meta-analyses have demonstrated that GLP-1RA and SGLT2i exhibit comparable protective effects, with both showing significant superiority over traditional hypoglycemic agents such as DPP-4i and sulfonylureas

Mounjaro works by mimicking two hormones in your gut, GLP-1 and GIP, that help control your appetite and blood sugar levels