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Especially in mutant KRAS tumors, linsitinib reached a significantly increased disease stabilization response in clinical trials (Jones et al., 2015)
At a glance Mechanism / GLP-1s reduce gastric-emptying rate by up to 35 to 40% at peak pharmacologic effect Highest-risk drug classes / narrow-therapeutic-index drugs, oral contraceptives, levothyroxine, warfarin, cyclosporine Semaglutide (Ozempic/Wegovy) label warning / explicitly notes potential to slow absorption of oral medications Tirzepatide (Mounjaro/Zepbound) label warning / same gastroparesis-like caveat applies Oral semaglutide (Rybelsus) / must be taken 30 min before any other oral drug or food Gastric emptying effect / greatest in first 4 to 8 weeks
Grundemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R et al
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