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Eur J Pharmacol909:
WHOs First Guidance: a Significant Milestone In December 2025, the World Health Organization issued its first-ever guidance on GLP-1 medications for obesity a major moment in global clinical policymaking
Conclusions and Lessons Learned The potential of DPP-4 inhibition as a glucose-lowering concept has now been explored for more than 25 years and it is more than 10 years since several DPP-4 inhibitors were introduced to the market (Figure 1)
A pooled analysis of semaglutide trials reported thyroid adverse events in less than 1% of participants
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