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Moreover, in the presence of FA, ADH5 cells showed the early apoptosis marker phosphatidylserine (measured by Annexin V), a blockage of the cell cycle at G2/M phase, and sub-G1 DNA accumulation (Supplementary Fig

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Regulation of the Pentose Phosphate Pathway The major regulator of the PPP is the cellular response to oxidative stress

In diff-ARPE19 cells, a lower dose of MOTS-c can reduce the negative impact of hypoxia on cellular survival and gene expression, including apoptosis ( CASP3, CASP9 ), mitochondrial biogenesis ( TFAM, PGC-1 ), and metabolic sensor ( AMPK )