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Statistical analysis For statistical analysis, the quantitative data with normal distribution were presented as the mean standard error (SEM), and the data with non-normal distribution were presented as median(25% percentile, 75% percentile)

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Preclinical studies indicate that GLP-1 RAs can attenuate atherosclerosis by reducing vascular inflammation, lowering oxidative stress, and inhibiting the proliferation and activation of vascular smooth muscle cells [51, 52]