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These exit interviews have allowed participants in SURMOUNT-4 to freely reflect on their experiences with tirzepatide and the clinical trial, and to share deeper insights not only related to their weight, physical functioning, and mental health, but also daily life, social life, physical appearance, work, and leisure time, based on what was noticeable and important to them

GABA receptors are widely expressed in the central nervous system (CNS) and occupy approximately 20% of the synapses in the cerebral cortex, hippocampus, thalamus, and cerebellum