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In addition, in the cases of methylmalonic acidemia with homocystinuria due to pathogenic variants in the methionine synthase (MTR) gene the consequent reductions in S-adenosylmethionine (SAM or AdoMet) synthesis results in loss of efficient phospholipid methylation leading to defects in myelin sheath membrane lipid homeostasis which contributes to the neural pathology of these disorders
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A weight loss diet typically includes less refined carbs and more fiber-rich food and lean meats
