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Proper dosing, monitoring, and individualized treatment planning are essential to ensure safe and effective results
First-line medications in the UK include: Methylphenidate (e.g., Concerta XL, Equasym XL, Medikinet XL)a stimulant that increases dopamine and noradrenaline availability Lisdexamfetamine (Elvanse)a prodrug stimulant for ADHD when significant impairment persists [19] [18] Atomoxetine (Strattera)a non-stimulant noradrenaline reuptake inhibitor, suitable when stimulants are contraindicated or ineffective Guanfacine (Intuniv)a non-stimulant alpha-2 adrenergic agonist licensed for children and adolescents aged 6-17 years Medication choice depends on individual factors including comorbidities (such as anxiety, tics, or substance misuse history), cardiovascular health, and patient preference
Take as prescribed for acute migraine
Exposures and Outcomes Exposures to the index medication were identified from outpatient dispensing records, where medication classes were defined by National Drug Codes based on Anatomical Therapeutic Chemical (ATC)-defined medication classes (ESM Table S2)
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