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Nutritional shifts during rapid weight loss may also reduce intake of essential fatty acids and minerals that support skin barrier integrity
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Quality-control risk for any research-use peptide (purity, contamination, mislabeling)
A 2018 study in Dermatologic Therapy found that 38% of patients experienced rebound hyperpigmentation within 812 weeks of discontinuing hydroquinone monotherapy, likely because melanocytes compensate for reduced tyrosinase activity by upregulating MITF (microphthalmia-associated transcription factor), the master regulator of melanocyte differentiation
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