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Eli Lilly launched a multi-dose KwikPen for Zepbound (four doses in one pen) Medicare and Medicaid do not cover either drug for weight loss alone in 2026 only for their other approved uses (Wegovy for cardiovascular risk

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This has been attributed in part to reduced expression of their receptors as a consequence of glucotoxicity [2], a possibility supported by the observation that normalisation of blood glucose levels in patients with type 2 diabetes restores the efficacy of GLP-1 and GIP [3]

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