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Acknowledgements We appreciate the technical support from the Research Support Center, Graduate School of Medical Sciences, Kyushu University and partial support from intramural research funds of NIDDK, NIH

Therefore, we speculate that applying incretin-based medications in PD models can promote insulin secretion, improve peripheral and central insulin resistance, stabilize mitochondrial function, enhance energy metabolism, and exert neuroprotective effects that stabilize dopamine homeostasis (88)

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A: Shelf life is 24 months when kept sealed, cold, dry and protected from light