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Since ceruloplasmin binds 85-95% of circulating copper and facilitates its safe transport, reduced synthesis means a higher fraction of "free" (non-ceruloplasmin-bound) copper in circulation
C., Camargo, L
GPX2 is a key antioxidant enzyme involved in the detoxification of reactive oxygen species (ROS), which are known mediators of cisplatin- and 5-FUinduced cytotoxicity [17,18,19,20]
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